Pharmacy dry granulation machine for western medicine

Pharmacy dry granulation machine for western medicine

$28000-120000 /Set/Sets

Payment Type:	T/T,L/C
Incoterm:	FOB,CFR,CIF,EXW,FCA
Min. Order:	1 Set/Sets
Transportation:	Ocean,Land,Air
Port:	Shanghai,Ningbo,Guangzhou

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Product Description

Product Attributes

Model No.: LG

Brand: Bole Tech

Place Of Origin: China

Old And New: New

Machine Type: Granulator

Video Factory Inspection: Provided

Mechanical Test Report: Provided

Core Component Warranty Period: 1 Year

Core Components: Plc, Gearbox

Warranty Period: 1 Year

Core Selling Point: Famous Brand Plc

Applicable Industry: Food &Amp; Beverage Factory, Energy &Amp; Mining, Other

Out-of-warranty Service: Field Maintenance And Repair Service, Online Support, Spare Parts, Video Technical Support

Where To Provide Local Services (in Which Countries Are There Overseas Service Outlets): Italy, Canada, United Kingdom, United States, Saudi Arabia, Malaysia, Australia

Showroom Location (in Which Countries Are There Sample Rooms Overseas): Italy, Turkey, Canada, United States, Bangladesh, Japan, Australia

Function: Dry granulation

Material Of Machine: SUS304/SUS316L

Material Of Roller: 3Cr13

Control System: Touch screen & PLC

Pressure Range: 0~25Mpa

Hydraulic Station: 0.75kW

Standard: GMP

Brand Of Control System: Siemens

Explosion-proof: Option

Customized: Support

Packaging & Delivery

Selling Units	:	Set/Sets
Package Type	:	Wooden case

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Roller compactor for dry granulation

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Product Description

In medicine manufacturing process operations, powder flowability—i.e., the ease with which powder flows through a system—affects the behavior of the material. As a result, it can have a significant impact on both the efficiency of the process and the quality of the finished product. Powder flow properties can very often be improved through the use of roller compaction/dry granulation technology. This is achieved by applying very high compression forces to densify a powder and then using a compression milling step to turn that densified material into granules of the desired size.

The science of the physical changes that transform a powder can be described as follows: Raw material powder in the form of a single component or homogenous powder blend is fed into a Roller compactor and delivered by means of a feedscrew to two counter rotating rollers for compaction. The rollers will apply hydraulic pressure to the powder that comes between them.

The material advances to the compaction zone using the friction of the powder against a spiral feedscrew. For very light or low bulk density powders, the addition of a vacuum filter helps to move the material into the process.

The material first begins to move into the compaction zone in the “Slip” region between the rollers. The powder particles are now moving closer together. In this area the friction of the roller surface interacting with the powder pulls the powder into the process.

In the next phase known as the “Nip” zone, the powder particles stop moving with reference to one another and begin moving with the same speed and position relative to the rollers. It is at this point that the particles begin to bend in a process known as “Plastic deformation”.

The further the particles are pulled into the process, the greater the pressure being exerted on them by the rollers. When particle bending cannot withstand the increasing pressure being exerted by the process, the particles will fracture. As the fractured particles near the point of maximum pressure, Van der Waals forces will form new bonds between the fractured particles creating a densified “flake” or “ribbon” that exits the rollers as compacted material.

The next step in the process is the granulation step wherein the densified material is sequentially broken into smaller pieces and then is pressed through a screen of a defined size with a rotating bar.

What results from this process is a material that has undergone a mechanical process to physically densify the material. In most cases, no additional binders, lubricants, or moisture need to be added to the process. The chemical nature of the original powder will remain unchanged.